We propose strategies to estimate and make inference on key features of heterogeneous effects in randomized experiments. These key features include best linear predictors of the effects using machine learning proxies, average effects sorted by impact groups , and average characteristics of most and least impacted units . The approach is valid in high‐dimensional settings, where the effects are proxied (but not necessarily consistently estimated) by predictive and causal machine learning methods. We post‐process these proxies into estimates of the key features. Our approach is generic; it can be used in conjunction with penalized methods, neural networks, random forests, boosted trees, and ensemble methods, both predictive and causal. Estimation and inference are based on repeated data splitting to avoid overfitting and achieve validity. We use quantile aggregation of the results across many potential splits, in particular taking medians of p ‐values and medians and other quantiles of confidence intervals. We show that quantile aggregation lowers estimation risks over a single split procedure, and establish its principal inferential properties. Finally, our analysis reveals ways to build provably better machine learning proxies through causal learning: we can use the objective functions that we develop to construct the best linear predictors of the effects, to obtain better machine learning proxies in the initial step. We illustrate the use of both inferential tools and causal learners with a randomized field experiment that evaluates a combination of nudges to stimulate demand for immunization in India.

Policymakers often choose a policy bundle that is a combination of different interventions in different dosages. We develop a new technique— treatment variant aggregation (TVA)—to select a policy from a large factorial design. TVA pools together policy variants that are not meaningfully different and prunes those deemed ineffective. This allows us to restrict attention to aggregated policy variants, consistently estimate their effects on the outcome, and estimate the best policy effect adjusting for the winner's curse. We apply TVA to a large randomized controlled trial that tests interventions to stimulate demand for immunization in Haryana, India. The policies under consideration include reminders, incentives, and local ambassadors for community mobilization. Cross‐randomizing these interventions, with different dosages or types of each intervention, yields 75 combinations. The policy with the largest impact (which combines incentives, ambassadors who are information hubs, and reminders) increases the number of immunizations by 44% relative to the status quo. The most cost‐effective policy (information hubs, ambassadors, and SMS reminders, but no incentives) increases the number of immunizations per dollar by 9.1% relative to the status quo.